Little Italy, Chicago, is a charming neighborhood that brings a slice of Italy to the Windy City. Known for its rich Italian-American heritage, authentic eateries, historic landmarks, and proximity to the University of Illinois at Chicago (UIC), Little Italy offers visitors a cozy, culturally rich experience. Whether you’re in town for food, history, or business near the Medical District, this guide to the Top 10 Hotels in Little Italy, Chicago will help you find the perfect place to stay.
1. Hyatt Place Chicago Medical/University District
Located right next to the Illinois Medical District and a short walk from Little Italy, this hotel is a top choice for travelers wanting convenience and comfort.
Why Stay Here: Ideal for visitors to UIC, Rush University Medical Center, and Little Italy’s restaurants.
Pros: Spacious rooms, complimentary breakfast, fitness center
Cons: Parking can be limited
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2. Marriott at Medical District/UIC
This Marriott property offers upscale accommodations just minutes from the heart of Little Italy.
Why Stay Here: Excellent for business travelers and those visiting the nearby hospitals.
Pros: Onsite restaurant, bar, modern amenities
Cons: Slightly higher price point
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3. The Emily Hotel (West Loop)
Though situated in the West Loop, The Emily Hotel is a short ride from Little Italy and offers chic, modern design with a creative flair.
Why Stay Here: Great for travelers who want to stay near trendy restaurants and bars while being close to Little Italy.
Pros: Rooftop bar, artistic design, pet-friendly
Cons: Nightlife may create noise
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4. Nobu Hotel Chicago
For a luxurious stay, Nobu Hotel in the nearby West Loop district offers an exquisite experience blending Japanese-inspired design with modern luxury.
Why Stay Here: High-end accommodations and dining, just minutes away from Little Italy.
Pros: Indoor pool, upscale Nobu restaurant
Cons: Expensive nightly rates
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5. Soho House Chicago
A boutique luxury hotel with a private members club atmosphere, located close to Little Italy in the West Loop.
Why Stay Here: For a premium stay with excellent amenities and exclusivity.
Pros: Rooftop pool, spa, fine dining
Cons: Some areas restricted to members only
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6. Holiday Inn & Suites Chicago Downtown
Located near Greektown and a short drive to Little Italy, this hotel offers clean, reliable accommodations.
Why Stay Here: Affordable yet comfortable, great for families or budget travelers.
Pros: Rooftop pool, fitness center, restaurant onsite
Cons: Lacks boutique charm
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7. Crowne Plaza Chicago West Loop
Located slightly north of Little Italy, this Crowne Plaza provides comfortable accommodations within walking distance of the neighborhood.
Why Stay Here: Great value and close to Fulton Market, Greektown, and Little Italy.
Pros: Business-friendly, onsite dining
Cons: Standard amenities, less boutique feel
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8. Hotel Chicago West Loop
A boutique hotel that offers art-inspired rooms, located conveniently between Little Italy and the West Loop.
Why Stay Here: Ideal for budget-conscious travelers who appreciate creative design.
Pros: Affordable rates, close to public transit
Cons: Smaller rooms
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9. Hampton Inn Chicago West Loop
Close to both West Loop and Little Italy, this Hampton Inn offers reliable accommodations with complimentary breakfast.
Why Stay Here: Comfortable stay with modern amenities at a reasonable price.
Pros: Free breakfast, fitness center, indoor pool
Cons: Basic decor
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10. La Quinta Inn & Suites by Wyndham Downtown Chicago
Just a short drive to Little Italy, this hotel is a practical choice for travelers seeking affordability without sacrificing comfort.
Why Stay Here: Great for budget travelers with easy access to public transportation.
Pros: Free breakfast, family-friendly
Cons: Standard hotel experience
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