South of Market, better known as SoMa, is one of San Francisco’s trendiest and most dynamic neighborhoods. Brimming with tech startups, art galleries, museums, and entertainment venues, SoMa is ideal for both business travelers and tourists. If you’re visiting San Francisco and want to stay close to attractions like the Moscone Center, SFMOMA, and Oracle Park, here are the top 10 hotels in SoMa for 2025.
1. St. Regis San Francisco
A luxury experience with impeccable service, the St. Regis is synonymous with sophistication.
- Why Stay Here: Proximity to SFMOMA and Yerba Buena Gardens.
- Pros: World-class spa, butler service, luxurious rooms.
- Cons: Expensive nightly rates.
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Hotels.com | Expedia | Orbitz
2. The Clancy, Autograph Collection
This art-inspired hotel caters to modern travelers, with contemporary designs and a youthful vibe.
- Why Stay Here: Centrally located near the Moscone Center.
- Pros: Stylish decor, pet-friendly.
- Cons: Some rooms can be small.
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Hotels.com | Expedia | Orbitz
3. Hotel VIA
Located across from Oracle Park, this boutique hotel offers sleek, modern rooms with views of the city.
- Why Stay Here: Perfect for sports fans and event-goers.
- Pros: Rooftop bar with stunning views.
- Cons: Limited amenities compared to larger hotels.
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Hotels.com | Expedia | Orbitz
4. InterContinental San Francisco
A towering glass hotel with panoramic city views and luxury amenities.
- Why Stay Here: Steps from Moscone Center.
- Pros: Indoor pool, high-end dining.
- Cons: Extra charges for parking and Wi-Fi.
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Hotels.com | Expedia | Orbitz
5. W San Francisco
Trendy and chic, W San Francisco is a favorite among younger travelers and professionals.
- Why Stay Here: Fun social spaces and modern design.
- Pros: Excellent location, lively atmosphere.
- Cons: Nighttime noise from the city.
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Hotels.com | Expedia | Orbitz
6. Hyatt Regency San Francisco Downtown SOMA
Freshly renovated, this hotel offers sophisticated comfort with easy access to Union Square and SoMa.
- Why Stay Here: Central for shopping and business.
- Pros: Spacious rooms, good amenities.
- Cons: Extra fees for certain services.
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Hotels.com | Expedia | Orbitz
7. Virgin Hotels San Francisco
A fun and funky hotel featuring vibrant rooms and a rooftop bar.
- Why Stay Here: Innovative design and tech-friendly features.
- Pros: Rooftop lounge, great atmosphere.
- Cons: Limited in-room dining options.
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Hotels.com | Expedia | Orbitz
8. Hotel Zetta San Francisco
Playful and artsy, this boutique hotel offers a creative environment with gaming areas.
- Why Stay Here: Perfect for creative professionals and gamers.
- Pros: Unique decor, central location.
- Cons: Smaller fitness center.
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Hotels.com | Expedia | Orbitz
9. San Francisco Marriott Marquis
A massive, iconic hotel offering sweeping views and modern comforts.
- Why Stay Here: Great for business travelers and conferences.
- Pros: Central location, rooftop lounge.
- Cons: Busy and large property.
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Hotels.com | Expedia | Orbitz
10. The Mosser Hotel
Budget-conscious travelers will appreciate this historic yet affordable hotel.
- Why Stay Here: Prime location near shopping and public transit.
- Pros: Affordable, historic charm.
- Cons: Small rooms, limited amenities.
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Hotels.com | Expedia | Orbitz
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